Welcome to . . . Iboganautics: Unveiling the iboga experience for first-timers and shamans alike. I’m your host, AM. Season 3, Neuro & Plant Science, is about how iboga-type alkaloids affect the human brain; neurophysiological and phenomenological overlaps between iboga and other hallucinogens; iboga botany; and ibogaine extraction methods. The main questions guiding this season are: How does iboga affect the brain, Which plant species produce iboga-type alkaloids, and How do scientists extract or “liberate” alkaloids from wood products? The first two episodes focus on neurophysiological and phenomenological overlaps between iboga and Salvia divinorum, and iboga and ketamine, respectively. Clinical psychologist Dr. Peter H. Addy (ep3.1) speaks about Salvia’s kappa opioid receptor agonist functions and we draw on both of our knowledge to find overlaps between Salvia and iboga. Ketamine clinician Dr. Lowan H. Stewart (ep3.2) and I discuss ketamine and iboga’s dissociative qualities and their shared NMDA receptor antagonist features. Organic chemist Dr. Surajit Sinha (ep3.3) guides us through the non-ibogaine alkaloid landscape, pointing out many other iboga-type alkaloids that get far less attention compared to ibogaine. Organic chemist Dr. Chris Jenks (ep3.4) is (in my opinion) the godfather of iboga extraction for it is he who discovered the extraction and purification process to make total alkaloid (TA) extract, changing the way people can experience iboga. Plant biologist Dr. Felix Krengel (ep3.5) expands upon Jenks’s work and takes extraction and purification of ibogan-type alkaloids to new levels, experimenting with different solvents in addition to focusing on the mostly voacangine-containing Tabernaemontana genus. And plant phenomenologist Dr. Michael Marder (ep3.6) explains what it is like to be a plant from the plant’s perspective and we philosophize about psychedelic plant sentience, intelligence, and agency upon their ingestion by humans. Keep an eye out for additional episodes to be released in Season 3. For more information about me and my work regarding psychedelic technology and philosophy of psychedelics in general, visit my website at https://amhouot.com/
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